The service life of carbon fiber reinforced epoxy (cf/ep) composites is determined by their wear and mechanical properties. Previous studies have often neglected the angle between the direction of friction and the direction of fiber alignment.In this study, cf/ep composites were made under orthogonal lamination and hot pressing conditions. The study simulated cross friction and three-point bending experiments to examine the impact of lamination order and ratio on tribological and mechanical properties. The results show that the friction coefficient is influenced by 66.7% due to the layup order, while the wear rate is affected by 33.3%.Furthermore, the study found an inverse relationship between the layup ratio and the friction coefficient.Additionally, there is a correlation between the angle of the fiber arrangement and the rate of transfer film formation. The rate of transfer film formation increases as the angle made by the load in the multidirectional layup through consecutive layups increases. The morphology analysis results indicate that the arrangement of fibers affects the wear mechanism. Specifically, when the friction direction is 0°, 45°, and 90° to the direction of carbon fiber arrangement, the corresponding wear mechanisms are slight abrasive wear, abrasive wear, and fatigue wear, respectively. These findings correspond to the gradual integrity of the transfer film. The mechanical data indicate that the position of the 45° ply has varying effects on bending resistance under different ratio conditions. When the 45° ratio is large, the flexural performance improves as the 45° ply gets closer to the surface layer. Conversely, when the ratio is small, the flexural performance improves as the 90° ply gets closer to the surface layer.Additionally, in all cases, the flexural performance improves as the 0° ply gets closer to the neutral surface.These results enhance our understanding of the friction and mechanical properties in cf/ep and provide guidance for the layup design of fiber-reinforced composites.