Abstract
Proper operating conditions have a significant impact on the process state of semi-batch reaction. However, various error and bias lead to the uncertainties of parameter, which affect process safety of the semi-batch reaction. In this work, the effect of dimensionless parameters dimensionless adiabatic temperature rise (), Westerterp number (Wt), , dimensionless activation energy (γ), volumetric heat capacity ratio (RH) and relative volume increase (ε) on the temperature of the isoperiodic homogeneous semi-batch reaction are investigated by local sensitivity analysis. The sensitivity of the dimensionless maximum temperature to global parameters is analyzed using the scatter plot method based on Monte-Carlo sampling. Parameter sensitivity results are further quantitatively calculated by the eFAST method. The results indicate that there is a strong linear relationship between the maximum reaction temperature and △τad,0, which exhibits the highest sensitivity index compared to the other parameters. The safety boundary diagram and adiabatic temperature diagram are constructed by considering parameter uncertainty and the effect of parameter uncertainty on the critical criteria is analyzed.