Professional experiment courses are important to students’ understanding and recognition of professional knowledge as links to professional experiments. The University of Science and Technology Beijing’s “Macro-Safety” discipline integration approach to safety engineering was used to develop safety engineering experimental courses. Development methods were discussed. A research background in multiple dominant disciplines helped establish the cultivation mode for innovation in students majoring in safety engineering. We combined the traditional teaching mode with multi-disciplinary, innovative experimental teaching, which improved the students’ enthusiasm for studying safety engineering, enhanced their practicality and innovation, and laid a solid foundation for their comprehensive development. The research results of this paper can be used in metallurgy, materials, and other related majors.