In the bi-directional design-construction cycle in architectural renewal practice, various uncertainty problems often arise due to the neglect of construction in the design stage, the separation of construction from design in the construction stage and the complex site environment of the scheme practice. Based on the architectural renewal practice of the Road and Bridge Laboratory of Southeast University, this paper sorts out the uncertainty problems in the process of design-construction and carries out typical reflections, expounds the design method of “Flexible reservation” for construction. Three strategies are proposed: redundant reservation under construction uncertainty, space definition of multi-job coordination, and technology integration in atmosphere creation, to provide experience for design-construction facing various uncertainties in current architectural renewal practice.